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Nebenwirkungen Levodopa Mechanism

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Häufig Gestellte Fragen

1What Is The Mechanism Of Action Of Levodopa?

Levodopa is in a class of medications called central nervous system agents. It works by being converted to dopamine in the brain. Carbidopa is in a class of medications called decarboxylase inhibitors. It works by preventing levodopa from being broken down before it reaches the brain.

2What Is The Mechanism Of Action Of Levodopa Carbidopa Selegiline?

Pharmacology. The mechanism of action of these medications involves inhibition of the COMT enzyme either in the periphery (entacapone) or in both the periphery and the CNS (tolcapone), thus providing another target for increasing the central availability of levodopa and its subsequent conversion to dopamine.

3How Does Levodopa Cross The Blood-Brain Barrier??

Specifically, levodopa is transported across the blood-brain-barrier (BBB) by the large neutral amino acid transporter (LAT1), which is expressed on the endothelial cells. Upon crossing the BBB, the drug is regionally decarboxylated to dopamine, which is stored in presynaptic monoaminergic terminals4.

4How Is Levodopa Converted Into Dopamine?

L-DOPA is converted to dopamine by the aromatic amino-acid decarboxylase enzyme in the blood. This source of dopamine causes peripheral side effects like nausea and reduces the amount of L-DOPA available to cross into the brain.

5What Is The Mechanism Of Action For Carbidopa Levodopa?

It works by being converted to dopamine in the brain. Carbidopa is in a class of medications called decarboxylase inhibitors. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting.

6Why Is Selegiline Used With Levodopa?

The action of selegiline is to inhibit monoamine oxidase (MAO) type B (and other MAOs at higher doses). The proposed mechanism of action is to inhibit the metabolism of dopamine in the CNS.

7How Does Selegiline Work In Parkinson’S Disease?

Selegiline is used in combination with levodopa or levodopa and carbidopa combination to treat Parkinson’s disease (sometimes called “shaking palsy” or “paralysis agitans”). This medicine works to increase and extend the effects of levodopa, and may help to slow the progress of Parkinson’s disease.